GLP-1 medications like semaglutide and tirzepatide can be powerful tools for supporting weight loss and blood sugar regulation, but they work best alongside good nutrition, movement, and lifestyle habits. Because these medications can significantly reduce appetite and slow digestion, it can become easier to under-eat protein and key nutrients, which may increase the risk of losing muscle along with fat and can affect digestion, energy, skin, and overall health. This guide is meant to be a starting place for your own research, with practical ideas around nutrition, movement, lifestyle, testing, and targeted support that you can explore further and bring to your health care provider to determine what may be appropriate for you. Be sure to refer to the attached protocol for additional guidance, as not every supplement listed is appropriate or necessary for everyone. Some may be added based on individual needs, symptoms, lab findings, medications, and overall health goals.